Half-baked (if that?) concept:
Superpowers are a thing. They kick in when you're, I don't know, like twenty or something, and are virginity-powered. They are explicitly available to literally anyone, and the group of people the setting/media/story follows is a balanced (50%~50%, more than three of each) mix of male and female.
I was picturing this as otherwise-completely-modern-world urban fantasy, probably with magical girl flavorings.
(Directly inspired by Sir Galahad as desrcibed here.